María Pilar Garcia-Sobreviela 1, María Angeles Alava 2, Hector Pejenaute 1, José M. Arbones-Mainar 1, 3 *
1 Adipocyte and Fat Biology Laboratory (AdipoFat). Unidad de Investigación Traslacional, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria (IIS) Aragón, Zaragoza
2 Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza.
3 CIBEROBN
* on behalf of the POLYFrEsNOL research group.
Background
Obesity is defined by excess adipose mass and oxidative stress has been positively associated with fat accumulation. Recent studies have shown the beneficial role of dietary antioxidants, such as polyphenols, in the prevention of obesity and obesity-related chronic diseases. Piceatannol, a natural phenolic compound, is an analog and a metabolite of resveratrol. It can be found in berries, passion fruit seeds, peanuts, grapes, red wine, and white tea.
Objectives and methods
Here, we investigated the function of piceatannol in adipogenesis in vitro using 3T3-L1 cells and adipocytes derived from human mesenchymal stem (hMSC) cells. [Leer más…]